The anticipated existence of a comprehensive
catalogue of all known human genes together with their nucleotide sequence
is intensifying research efforts on exploration of gene function both individually
and collectively at the molecular, cellular, organismal and population
level. The immense quantity of data being generated is just the beginning
of this revolution. The next great challenge is now upon us - to provide
meaning to this vast catalog of information, a challenge orders-of-magnitude
more difficult than previously faced. Knowing which gene networks are not
functioning properly, or which genetic variants influence disease predisposition
in an organism, contributes significantly to the ability to develop effective
clinical interventions for any particular disease.
To meet these challenges,
the University of North Carolina has initiated an unprecedented phase
of growth and expansion in human genetics, molecular genetics, gene expression,
developmental genetics, genome mapping and organization, genetic epidemiology,
statistical genetics and biostatistics. The result is exciting research
programs and training in all aspects of genetics, in organisms ranging
from plants,
Drosophila
and C. elegans to mouse and human genetics. This initiative in genetics
and genomics has led to the establishment of a new Department of Genetics
within the School of Medicine and a University-wide center for Genetics
and Genomics. A basic research program in genetics and genomics within
the context of a major University such as UNC represents an exciting
paradigm
for bench-to-bedside research.
The research approaches being applied
range from large-scale genome sequencing to the micro-scale assaying
of the metabolic
state of a single cell. However, all approaches share the theme of integrating
biology with technology and maximizes the use of computational data
analysis and management. The application of the tools of genetics/genomics
will
have a profound impact on scientific discovery, the delivery of health
care, the legal system and on many aspects of our culture and society.
Genetics at UNC is fast becoming a leader in establishing as well as
maximizing the use of these emerging technologies.
