The Perspective is entitled "Genetics Driving Epigenetics."
Dr. Sharpless succeeds H. Shelton “Shelley” Earp, MD, as center director effective January 1, 2014.
In collaboration with groups at three other institutions, they identified different miRNAs that are critical "regulatory hubs" in the immune response to the parasites Leishmania major and Schistosoma mansoni.
Chuck has been honored with the 2013 Hyman L. Battle Distinguished Cancer Research Award in recognition of his accomplishments in cancer research.
A research article highlights a method for prioritizing variants in miRNAs by their functional significance. Two Thematic Reviews are included in a special section of the Journal of Lipid Research.
The article by Jim Evans discusses the importance of the involvement of knowledgeable health care providers in communicating complex genomic information to patients and research subjects.
Triangle Business Journal on Tuesday unveiled 29 finalists for its 2013 Health Care Heroes Awards. Chuck and colleagues have also recently published an article in The Oncologist
Karen Mohlke is corresponding author on a paper reporting low-frequency variants in three new genes associated with abnormal insulin production or processing.
Ned Sharpless and colleagues have developed a mouse model that makes it possible to visualize tumor growth by means of a "knocked-in" p16 gene linked to a luciferase reporter.
An investigation into diabetes-related outcomes in a rat model, with senior author William Valdar, PhD, assistant professor of genetics at UNC, and first author Leah Solberg Woods, PhD, from the Medical College of Wisconsin, has made the editor's pick in this month's Physiological Genomics, a journal of the American Physiological Society.
Title of the paper is "MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia," published in the February 2013 issue.
"By expanding the field’s focus from common to rare diseases, it may be possible to realize the promise of public health genomics by identifying those millions of individuals who unknowingly carry mutations that confer a dramatic predisposition to preventable diseases."
Mauro Calabrese, a postdoctoral fellow in Terry Magnuson's lab, is first-author of an article in Cell
Paper titled "Site-Specific Silencing of Regulatory Elements as a Mechanism of X Inactivation."