The Perspective is entitled “Genetics Driving Epigenetics.”
The article discusses three reports on DNA variants in the human genome that affect gene regulation epigenetically, via sequence-specific binding-affinity of transcription factors. The results of these studies suggest a model in which the differential binding leads to variation in histone tail modification. In some cases, these variations lead to differences in gene expression, which can manifest as phenotypic variation for quantitative traits in the population.