Swislocki, N.I., Magnuson, T., and Tierney, J. (1977). Properties
of rat liver plasma membrane adenylate cyclase after chromatography
on 0- diethylaminoethyl-cellulose and agarose-hexane-GTP. Arch.
Biochem. Biophys. 179, 157-165.
Magnuson, T. and Stackpole, C.W. (1978). Lectin-mediated agglutination
of preimplantation mouse embryos. Exp. Cell Res. 116, 466-469.
Magnuson, T., Jacobson, J.B., and Stackpole, C.W. (1978). Relationship
between intercellular permeability and junction organization in
the preimplantation mouse embryo. Dev. Biol. 67, 214-224.
Bennett, D., Artzt, K., Magnuson, T., and Spiegelman, M. (1979).
Developmental interactions studied with experimental teratomas
derived from mutants at the T/t locus in the mouse. In Cell Interactions
in Differentiation (eds: M. Karkinen-Jaaskelainen, L. Saxen, and
L. Weiss), pp. 389-398. Academic Press, New York.
Magnuson, T. and Epstein, C.J. (1981). Characterization of concanavalin
A precipitated proteins from early mouse embryos: A 2 dimensional
gel electrophoresis study. Dev. Biol. 81, 183-199.
Magnuson, T. and Epstein, C.J. (1981). Use of concanavalin A to
monitor changes in glycoprotein synthesis during early mouse development.
In Cellular and Molecular Aspects of Implantation (eds: S.R. Glasser
and D.W. Bullock), pp. 409-411. Plenum Press, New York.
Magnuson, T and Epstein, C.J. (1981). Genetic control of very
early mammalian development. Biol. Rev. 56, 369-408.
Sawicki, J., Magnuson, T., and Epstein, C.J. (1981). Paternal
gene expression of ß2-microglobulin in preimplantation
mouse embryos. Nature 294, 450-451.
Epstein, C.J. and Magnuson, T. (1982). Genetic control of early
mammalian development, In Human Genetics, Part A: The Unfolding
Human Genome (eds: B. Bonne-Tamir, T. Cohen, R.M. Goodman), pp.
327-338. A.R. Liss, New York.
Magnuson, T., Smith, S., and Epstein, C.J. (1982). The development
of monosomy 19 mouse embryos. J. Embryol. Exp. Morphol. 69, 223-236.
Epstein, C.J., Smith, S., Zamora, T., Sawicki, J.A., Magnuson,
T., and Cox, D. (1982). The production of viable adult trisomy
17<-->diploid mouse chimeras. Proc. Natl. Acad. Sci. USA
79, 4376-4380.
Magnuson, T., Epstein, C.J., Silver, L.M., and Martin, G. (1982).
Pluripotent embryonic stem cell lines can be derived from tw5/tw5
blastocysts. Nature 298, 750-753.
Magnuson, T. (1983). Genetic abnormalities and early mammalian
development. In Development in Mammals (ed: M.H. Johnson), pp.
209-249.
Magnuson, T., Martin, G., Silver, L.M., and Epstein, C.J. (1983).
Studies of the viability of tw5/tw5 embryonic cells in vitro and
in vivo. In Cold Spring Harbor Conferences on Cell Proliferation,
Vol. 10: Teratocarcinoma Stem Cells. pp. 671-681.
Epstein, C.J., Cox, D.R., Epstein, L.B., and Magnuson, T. (1984).
Animal models for human chromosome disorders. In Research Perspectives
in Cytogenetics. (eds: F. de La Cruz and R.S. Sparkes), pp. 75-95.
University Park Press, Baltimore.
Magnuson, T. and Epstein, C.J. (1984). Oligosyndactyly: A lethal
mutation in the mouse that results in a mitotic arrest very early
in development. Cell 38, 823-833.
Magnuson, T., Debrot, S., Dimpfl, J., Zweig, A., Zamora, T., and
Epstein, C.J. (1985). The early lethality of autosomal monosomy
in the mouse. J. Exp. Zool. 236, 353-360.
Magnuson, T. (1986). Mutations and chromosomal abnormalities:
How are they useful for studying genetic control of early mammalian
development? In Experimental Approaches to Mammalian Embryonic
Development (eds: J. Rossant and R. Pedersen). pp. 437-474, Cambridge
University Press.
Magnuson, T. and Epstein, C.J. (1987). Genetic activity during
early embryonic development. In The Mammalian Preimplantation Embryo:
Regulation of Growth and Differentiation In Vitro (ed: B. Bavister).
pp. 130-150, Plenum Press, New York.
Yee, D., Golden, W., Debrot, S., and Magnuson, T. (1987). Short-term
rescue by RNA injection of a mitotic arrest mutation that affects
the preimplantation mouse embryo. Dev. Biol. 122, 256-261.
Niswander, L., Edström, J.E., Rinchik, E.M., and Magnuson,
T. (1989). Genetics of early embryo survival. In Transgenic Models
in Medicine and Agriculture. UCLA Symposia on Molecular and Cellular
Biology, New Series, Vol. 116. Editor, R. Church, A.R. Liss,
Inc., New York, NY.
Niswander, L., Yee, D., Rinchik, E.M., Russell, L.B., and Magnuson,
T. (1988). The albino-deletion complex and early postimplantation
survival in the mouse. Development 102, 45-53.
Niswander, L., Yee, D., Rinchik, E.M., Russell, L.B., and Magnuson,
T. (1989). The albino-deletion complex uncovers genes necessary
for development of embryonic and extraembryonic ectoderm. Development,
105, 178-182.
Hiraoka, L., Golden, W., and Magnuson, T. (1989). Centrosome organization
during early mouse development. Develop. Biol., 133, 24-36.
Lin, C., Magnuson, T., and Samols, D. (1989). A rapid procedure
to identify newborn transgenic mice. DNA 8, 297-299.
Niswander, L., Kelsey, G.,Schedl, A., Sharon, S., Holdener, B.,
Rinchik, E.M., Edström, J.E., and Magnuson, T. (1991). Molecular
mapping of albino deletions associated with early embryonic lethality.
Genomics 9, 162-169.
Sharan, S.K., Holdener-Kenny, B., Ruppert, S., Schedl, A., Kelsey,
G., Rinchik, E.M. and Magnuson, T. (1991). The albino-deletion
complex of the mouse: Molecular mapping of deletion breakpoints
that define regions necessary for development of the embryonic
and extraembryonic ectoderm. Genetics 129, 825-832.
Magnuson, T., Sharan, S. and Holdener-Kenny, B. (1992). Mutations
affecting development in the mouse. in Preimplantation Embryo Development.
Editor, Bavister, B., Springer-Verlag. New York. pp. 131-143.
Sharan, S.K., Holdener-Kenny, B., Threadgill, D. and Magnuson,
T. (1992). Genomic mapping within the albino-deletion complex using
individual early postimplantation mouse embryos. Mammalian Genome
3, 79-83.
Rinchik, E.M., Magnuson, T., Holdener-Kenny, B. Kelsey, G., Bianchi,
A., Conti, C.J., Chartier, F., Brown, K.A., Brown, S.D.M., and
Peters, J. (1992). Mouse chromosome 7. Mammalian Genome 3, S104-S120.
Holdener-Kenny, B., Sharan, S.K., and Magnuson, T. (1992). Albino
Deletions: From genetics to genes in development. BioEssays 14,
831-839.
Kelsey, G., Schedl, A., Ruppert, S., Klebig, M.L., Niswander,
L., Magnuson, T., Rinchik, E.M. and Schütz, G. (1992). Physical
mapping of the albino-deletion complex in the mouse to localize
alf/hsdr-1, a locus required for neonatal survival. Genomics
14, 275-287.
Schedl, A., Ruppert, S., Kelsey, G., Thies, E., Niswander, L.,
Magnuson, T., Klebig, M., Rinchik, E.M., and Schütz, G.
(1992). Chromosome jumping from flanking markers defines the
minimal region
for alf/hsdr-1 within the albino-deletion complex. Genomics 14,
288-297.
Faust, C. and Magnuson, T. (1993). Genetic control of gastrulation
in mouse. Curr. Opinions in Genetics and Development 3, 491-498.
Toltzis, P., Mourton, T., and Magnuson, T. (1993). Zidovudine
prevents implantation of murine embryos. Antimicrob. Agents Chemother.
37, 1610-13.
Holdener, B.C., Brown, S.D.M., Angel, J.M., Nicholls, R.D., Kelsey,
G. and Magnuson, T. (1993). Mouse chromosome 7. Mammalian Genome
S110-S120.
Tomasiewicz, H., Ono, K., Yee, D., Thompson, C., Goridis, C.,
Rutishauser, U. and Magnuson, T. (1993). Genetic deletion of a
neural cell adhesion molecule variant (NCAM-180) produces distinct
defects in the central nervous system. Neuron 11, 1163-1174.
Holdener, B.C. and Magnuson, T. (1994). Mouse model for human
hereditary tyrosinemia I. BioEssays 16, 85-87.
Toltzis, P., Mourton, T., and Magnuson, T. (1994). Comparative
embryonic cytotoxicity of antiretroviral nucleosides. J. Infec.
Dis. 169, 1100-1102.
Holdener, B.C., Faust, C. and Magnuson, T. (1994). msd is required
for mesoderm induction in mouse. Development 120, 1335-1346.
Ono, K., Tomasiewicz, H., Magnuson, T., Rutishauser, U. (1994).
Polysialic acid promotes rostral cell migration in the subependymal
layer of the mouse.Neuron 13, 595-609.
Thomas, J.W., Holdener, B.C. and Magnuson, T. (1994). Sequence
analysis of a radiation induced deletion breakpoint. Mammalian
Genome 5, 518-519.
Faust, C., Shumacher, A., Holdener, B., and Magnuson, T. (1995).
The eed mutation disrupts anterior mesoderm production in mice.
Development, 121, 273-285.
Chakravarti, S. and Magnuson, T. (1995). Mouse lumican (keratan
sulfate proteoglycan): Partial coding sequence and localization
to distal chromosome ten. Mammalian Genome 6, 367-368.
Holdener, B.C., Rinchik, E.M. and Magnuson, T. (1995). Phenotypic
and physical analysis of a chemically induced mutation disrupting
anterior axial development in the mouse. Mammalian Genome 6, 474-475.
Rabinowitz, J.E. and Magnuson, T. (1995). Independent gene targeting
by coelectroporation of multiple vectors. Analyt. Biochem., 228,
180-182.
Threadgill, D.W., Dlugosz, A.A., Hansen, L., Tennenbaum, T., Lichti,
U., Yee, D., LeMantia, C., Mourton, T., Herrup, K., Harris, R.C.,
Barnard, J.A., Yuspa, S.H., Coffey, R.J. and Magnuson, T. (1995).
Targeted disruption of mouse EGF-receptor: Effect of genetic background
on mutant phenotype. Science, 269, 230-234.
Holdener, B.C., Thomas, J.W., Schumacher, A., Potter, M.D., Rinchik,
E.M., Sharan, S.K. and Magnuson, T. (1995). Physical localization
of eed: A region of mouse chromosome 7 required for gastrulation.
Genomics 27, 447-456.
Magnuson, T. and Faust, C.J. (1995). Vertebrate gastrulation and
axial patterning: An editorial overview Part I. Dev. Genetics 17,
1-5.
Magnuson, T. and Faust, C.J. (1995). Vertebrate gastrulation and
axial patterning: An editorial overview Part I. Dev. Genetics 17,
103-106.
Weng, A., Magnuson, T., and Storb, U. (1995). Strain-specific
transgene methylation occurs early in mouse development and can
be recapitulated in embryonic stem cells. Development, 121, 2853-2859.
Rennebeck, G.M., Lader, E.S., Chen, Q., Cai, Z.S., Faust, C.,
Magnuson, T., Pease, L.R., and Artzt, K. (1995). Is there a Brachyury
the Second? Analysis of a transgenic mutation involved in notochord
maintenance in mice. Develop. Biol., 172, 206-217.
Lin, C.S., Xia, D., Yun, J.S., Wagner, T., Magnuson, T., Mold,
C. and Samols, D. (1995). Expression of rabbit c-reactive protein
in transgenic mice. Immunol. Cell. Biol. 73, 521-531.
Tong, B.J., Das, S.K., Threadgill, D., Magnuson, T., and Dey,
S.K. (1996). Differential expression of the full-length and truncated
forms of the epidermal growth factor receptor in the preimplantation
mouse uterus and blastocyst. Encocrinology, 137, 1492-1496.
Denning, M.F., Dlugosz, A.A., Threadgill, D.W., Magnuson, T.,
and Yuspa, S.H. (1996). Activation of the epidermal growth factor
receptor signal transduction pathway stimulates tyrosine phosphorylation
of protein kinase C d. J. Biol. Chem., 271, 5325-5331.
Hu, H., Tomasiewicz, H., Magnuson, T., and Rutishauser, U. (1996).
The role of polysialic acid in migration of olfactory bulb interneuron
precursors in the subventricular zone. Neuron, 16, 735-743.
Rabinowitz, J.E., Rutishauser, U. and Magnuson, T. (1996). Targeted
mutation of Ncam to produce a secreted molecule resulting in a
dominant embryonic lethality. Proc. Natl. Acad. Sci. USA 93, 6421-6424.
Ewulonu, K., Schimenti, K. Kuemerle, B., Magnuson, T., and Schimenti,
J. (1996). Targeted mutagenesis of a candidate t complex responder
gene in mouse t haplotypes does not eliminate transmission ratio
distortion. Genetics 144, 785-792.
Saga, Y., Hata, N., Kobayashi, S., Magnuson, T., Seldin, M.F.,
and Taketo, M.M. (1996). MesP1: A novel basic helix-loop-helix
protein expressed in the nascent mesodermal cells during mouse
gastrulation. Development 122, 2769-2778.
Schumacher, A., Faust, C.J. and Magnuson, T. (1996). Positional
cloning of a global regulator of anterior-posterior patterning
in mice. Nature 383, 250-253.
Hansen, L.A., Lichti, U., Tennenbaum, T., Dlugosz, A.A., Threadgill,
D.W., Magnuson, T., and Yuspa, S.H. (1996). Altered hair follicle
morphogenesis in epidermal growth factor deficient mice. In Hair
Research for the Next Millenium, Eds. Van Neste and Randall, Elsevier
Science BV, pg. 425-431.
Schumacher, A. and Magnuson, T. (1997). Murine polycomb- and trithorax-group
genes regulate homeotic pathways and beyond. Trends in Genetics
13, 167-170.
Hansen, L.A., Alexander, N., Tennenbaum, T., Hogan, M.E., Sundberg,
J.P., Threadgill, D.W., Magnuson, T. and Yuspa, S. (1997). Genetically
null mice reveal a central role for EGFR in the maturation of the
hair follicle and normal hair development. Amer. J. Pathol 150,
1959-1975.
Shen, H., Watanabe, M., Tomasiewicz, H., Rutishauser, U., Magnuson,
T., and Glass, J.D. (1997). Mutation or enzymatic perturbation
of polysialylated NCAM disrupts circadium function in the mouse.
J. Neurosci. 17, 5221-5229.
Dlugosz, A.A., Hansen, L., Cheng, C., Alexander, N., Denning,
M.F., Threadgill, D.W., Magnuson, T., Coffery, R.J. & Yuspa,
S.H. (1997) Targeted disruption of the epidermal growth factor
receptor impairs growth of squamous papillomas expressing the
v-rasHa oncogene but does not block in Vitro keratinocyte responses
to
oncogenic ras. Cancer Res. 57, 3180-3188.
Threadgill, D.W., Yee, D., Matin, A., Nadeau, J.H., and Magnuson,
T. (1997). Geneology of the 129 inbred strains: 129/SvJ is a contaminated
inbred strain. Mammalian Genome 8, 390-393.
Threadgill, D.W., Matin, A., Yee, D., Carrasquillo, M.M., Henry,
K.R., Rollins, K.G., Nadeau, J.H., and Magnuson, T. (1997). SSLPs
to map genetic differences between the 129 inbred strains and closed-colony
random bred CD-1 mice. Mammalian Genome 8, 441-442.
Treloar, H.B., Tomasiewicz, H., Magnuson, T., and Key, B. (1997).
The central pathway of primary olfactory axons is abnormal in mice
lacking the N-CAM-180 isoform., J. Neurobiol. 32, 643-58.
Johnson, M.T., Yang, H.-S., Magnuson, T., Patel, M.S. (1997).
Targeted disruption of the murine dihydroliposamide dehydrogenase
gene (Dld) results in perigastrulation lethality. Proc. Natl. Acad.
Sci. U.S.A. 94, 14512-14517.
Thomas, J., LaMantia, C.L., and Magnuson, T. (1998). X-ray-induced
mutations in mouse embryonic stem cells. Proc. Natl. Acad. Sci.
U.S.A. 95, 1114-1119.
van Lohuizen,M., Tijms, M., Voncken,J.W., Schumacher, A., Magnuson,
T., and Wientjens, E (1998). Interaction of mouse Pc-G proteins
Enx1 and Enx2 with Eed: Indication for separate Pc-G complexes.
Mol. Cell. Biol., 18, 3572-2579.
Chakravarti, S., Magnuson, T., Lass, J.H., Jepsen, K.J., LaMantia,
C., and Carroll, H. (1998). Lumican regulates collagen fibril assembly:
skin fragility and corneal opacity in the absence of lumican. J.
Cell Biol., 141, 1277-1286.
Woychik, R.P., Klebig, M.L., Justice, M.J., Magnuson, T. and Avner,
E. (1998). Functional genomics in the post-genome era. Mutation
Res., 400, 3-14.
Wood, G.K., Tomasiewicz, H., Rutishauser, U., Magnuson, T., Quirion,
R., Rochford, J., Srivastava, L.K. (1998). NCAM-180 knockout mice
display increased lateral ventricle size and reduced prepulse inhibition
of startle. Neuroreport 9, 461-466.
Shapiro, D.A., Threadgill, D.S., Copfer, M.H., Corey, D.A., McCool,
T.L., McCormick, L.L., Magnuson, T., Greenspan, N.S., Schreiber,
J.R. (1998). G3 gene-disrupted mice selectively deficient in the
dominant IgG subclass made to bacterial polysaccharides undergo
normal isotype switching after immunization with polysaccharide-protein
conjugate vaccines. J. Immunol., 161, 3393-3399.
Schumacher, A., Lichtarge, O., Schwartz, S., and Magnuson, T.
(1998). The murine Polycomb-group gene eed and its human orthologue:
Functional implications of evolutionary conservation. Genomics,
54, 79-88.
Faust, C., Lawson, K.A., Schork, N.J., Thiel, B., and Magnuson,
T.(1998). The Polycomb-group gene eed is required for normal morphogenetic
movements during gastrulation in the mouse embryo. Development,
125; 4495-4506.
Lessard, J., Schumacher, A., Thorsteinsdottir, U., van Lohuizen,
V., Magnuson, T. and Sauvageau, G. (1999). Functional antagonism
of the Polycomb-group genes eed and Bmi1 in hemopoietic cell proliveration.
Genes Dev. 13, 2691-2703.
Bultman, S. and Magnuson, T. (2000). Classical Genetics and Gene
Targeting. In: Gene Targeting: A Practical Approach, 2nd edition.
Ed. Joyner. A.L. Oxford University Press, pp. 255-283.
Bultman, S.J., Green, P. and Magnuson, T. (2000). Genetic modification
of mutant receptor phenotypes. In: Genetic manipulation of receptor
expression and function. Ed. Acelli, D. Wiley Interscience, NY,
pp. 39-53.
Wang, J., Tie, F., Jane, E., Schumacher, A., Harte, P.J. and Magnuson,
T. (2000). Mouse Homolog of the Drosophila Pc-G gene esc exerts
a dominant negative effect in Drosophila. genesis: J. Genet. Develop.
26, 66-76.
Chen, C., Bronson, R.T., Klaman, L.D., Hampton, T.G ., Wang, J.,
Green, P.J ., Magnuson, T., Douglas, P.S ., Morgan, J.P & Neel,
B.G (2000). Mice mutant for Egfr and Shp2 have defective cardiac
semilunar valvulogenesis Nature Genetics 24, 296-299.
Chen, Y., Yee, D., Chatterjee, A., Dains, K., Schneider, E., Om,
J., Woychik, R. and Magnuson, T. (2000). Genotype-based screen
ENU-induced mutations in mouse embryonic stem cells. Nature Genetics,
24, 314-317.
Geburh, T.C., Bultman, S.J. and Magnuson, T. (2000). Pc-G/trx-G
and the SWI/SNF connection: developmental gene regulation through
chromatin remodeling. genesis: The J. Genet. Develop., 26, 189-197.
Bultman, S. and Magnuson, T. (2000). Molecular and genetic analysis
of the mouse homolog of the Drosophila Suppressor of Position Effect
Variegation 3-9 gene. Mammalian Genome, 11, 251-254.
Denning, MF, Dlugosz, AA, Cheng, C, Dempsey, PJ, Coffey, RJ, Threadgill,
D.W., Magnuson, T, and Yuspa, SH. (2000). Cross-talk between epidermal
growth factor receptor and protein kinase C during calcium-induced
differentiation of keratinocytesExp Dermatol 9, 192-199.
Chen, Y., Schimenti, J., and Magnuson, T. (2000). Toward the Yeastification
of Mouse Genetics: Chemical Mutagenesis of Embryonic Stem Cells.
Mammalian Genome 11, 598-602.
Kendall, S.K., Strong, S.J., Litman, R.T., Litman, G.W. and Magnuson,
T. (2000). Genetic analysis of the exed region in mouse. Genesis.
27, 174-179.
Bultman, S, Yee, D., LaMantia, C., Nicholson, J., Gilliam, A.,
Randazzo, F., Metzger, D., Chambon, P., Crabtree, G., and Magnuson,
T. (2000). A Brg1 null mutation in the mouse reveals functional
differences among mammalian SWI/SNF complexces. Molecular Cell,
6, 1287-1295.
Reiter, J.L., Threadgill, D.W., Eley, G.D., Strunk, K.E., Danielsen,
A.J., Sinclair, C.S., Pearsall, R.S., Green, P.J., Yee, D., Lampland,
A.L., Balasubramaniam, S., Crossley, R.D., Magnuson, T.R., James,
C.D., and Maihle, N.J. (2001). Comparative genomic sequence analysis
and isolation of human and mouse alternative EGFR transcripts encoding
truncated receptor isoforms. Genomics 71, 1-20.
Mager,
J. and Magnuson, T. (2001). Mouse Radiation Genetics. In Encyclopedia
of Genetics, S. Brenner and J. Miller, Eds. Academic
Press.
The International Mouse Mutagenesis Consortium (2001). Annotating
genome sequences with biological functions in mice, Science, 291,
1251-1255.
Wang, J., Mager, J., Chen, Y., Schneider, E., Cross, J., Nagy,
A., and Magnuson, T. (2001). Imprinted X inactivation maintained
by a Polycomb-group gene.
Nature Genetics 28, 371-375.
Richie, E.R., Schumacher, A., Angel, J.M., Holloway, M., Rinchik,
E.M., and Magnuson, T. (2002). The Polycomb-group gene eed affects
thymocyte differentiation and suppresses the development of carcinogen-induced
T-cell lymphomas. Oncogene, 21, 299-306.
Morin-Kensicki, E.M., Faust, C., LaMantia, C. and Magnuson, T.
(2002). Cell and tissue requirements for the gene eed during mouse
gastrulation and organogenesis. genesis, 31, 142-146.
Wang, J., Mager, J. Schneider, E. and Magnuson, T. (2002). The
mouse PcG gene eed is required for Hox gene repression and extraembryonic
development. Mammalian Genome 13, 493-503.
Schwarz, D.G., Schneider, E.A., Yee, D., Griffin, C.T. and Magnuson,
T. (2002). Genetic analysis of Sorting Nexins 1 and 2 reveals a
redundant and essential function in mice. Molec. Biol. Cell. 13,
3588-3600.
Vivian, J., Chen, Y., Yee, D., Schneider, E., and Magnuson, T.
(2002). An allelic series of mutations in Smad2 and Smad4 identified
in a genotype-based screen of N-ethyl-N-nitrosourea-mutagenized
mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA, 99, 15542-15547.
Mager, J.C., Montgomery, N.D., Pardo-Manuel de Villena, F. and
Magnuson, T. (2003). Genome imprinting regulated by a mouse polycomb
group protein. Nature Genetics, 33, 502-507 (note News & Views
commentary pg 1-2).
Fan, Y., Nikitina, T., Morin-Kensicki, E. Zhao, J., Magnuson,
T.,
Woodcock, C. and Skoultchi, A. (2003). H1 histones are essential
for mouse
development and affect nucleosome spacing in vivo. Mol. Cell. Biol
23,
4559-4572 .
Rivera-Pérez, J., Mager, J. and Magnuson, T. (2003). Dynamic
morphogenetic changes characterize the mouse visceral endoderm.
Dev. Biol.,
15, 470-487.
Gebuhr, T., Kovalev, G.I., Bultman, S., Godfrey, V., Su, L., and
Magnuson, T. (2003). The role of Brg1, a catalytic subunit of mammalin
chromatin remodeling complexes, in T cell development. J. Exp.
Med., 198,
1937-1949.
Nadler, J.J., Moy, S.S., Dold, G., Perez, A., Young, N.B., Barbara,, R.P., Piven, J.,, Magnuson, T., and Crawley, J.N. (2004). Automated apparatus for quantitation of social approach behaviors in mice. . Gene, Brain, Behavior. 3, 303-314.
Moy, S.S., Nadler, J.J., Perez, A., Barbara, R.P., Johns, J.M., Magnuson, T., Piven, J., and Crawley, J.N. (2004). Modeling autism sociability and preference for social novelty tests in inbred strains of mice. Gene, Brain, Behavior. 3, 287-302.
Bultman, S., Montgomery, N., and Magnuson, T. (2004). Chromatin modeling factors and transcriptional regulation during development. In Handbook of Stem Cells, Volume 2: Embryonic Stem Cells. pp, 63-90. Ed. R. Lanza
Vivian, J., Chen, Y., and Magnuson, T. (2004). Mutational Analysis of Early Development Genes. In Handbook of Stem Cells, Volume 2: Embryonic Stem Cells. pp. 599-608. Ed. R. Lanza
Ideraabdullah, F.Y., del la Casa-Espereón, E., Bell, T.A., Detwiler, D.A., Magnuson, T., Sapienza, C., Pardo-Manuel de Villena, F. (2004). Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res. 14, 1880-1887.
Montgomery, N.D., Yee, D., Che A., Kalantry, S., Chamberlain, S.J., Otte, A.J., Magnuson, T. (2005). The Murine Polycomb Group Protein Eed is Required for Global Histone H3 Lysine-27 Methylation. Current Biol., 15, 942-947.
Moy, Shery, S., Nadler, J.J., Magnuson, T.R., and Crawley, J.N. (2005). Mouse Models for Autistic Spectrum Disorders: The Challenge for Behavioral Genetics. Amer, J. Human Genetics, In Press.
Griffin, C.T., Trejo, J., and Magnuson, T. (2005). Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc. Natl. Acad. Sci., 102,15173-15177.
Abell, A. N., Rivera-Perez, J. A.,Cuevas, B. D., Uhlik, M. T., Sather, S., Johnson, N. L., Minton, S. K., Lauder, J. M., Winter-Vann, A. M., Nakamura, K., Magnuson, T., Vaillancourt, R. R., Heasley, L. E., Johnson, G. L. (2005). Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol. Cell. Biol. 25, 8948-8959.
Rivera-Pérez, J., and Magnuson, T. (2005). Primitive streak formation in mice is preceded by localized activation of Bracyury and Wnt3. Develop. Biol.,288, 363-371.
Bultman, S.J., Gebuhr, T.C. and Magnuson, T. (2005). A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in b-globin expression and erythroid development. Genes & Develop.19, 2849-2861.
Committee on Guidelines for Human Embryonic Stem Cell Research: Hynes, R.O., Moreno, J.D., Price Foley, E., Fost, N., Horvitz, H.R., Imbrescia, M., Magnuson, T., Mwaria, C., Rossant, J., Rosley, J.D. (2005). Guidelines for Human Embryonic Stem Cell Research. The National Academies Press, Washington, D.C.
Morin-Kensicki, E.M., Boone, B.N., Howell, M., Stonebraker, J.R., Teed, J., Alb, J.G., Magnuson, T.R., O’Nel, W., Milgram, S.L. (2006). Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65” and with author list as follows. Molec. Cell. Biol, 26, 77-87.
Kalantry, S., Mills, K.C., Yee, D., Otte, A.P., Panning, B. and Magnuson, T. (2006). The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nature Cell Biol. 8 195-202.
Chen, Y., Yee, D. and Magnuson, T. (2006). A novel mouse Smad4 mutation reduces protein stability and wild type protein levels. Mammalian Genome 17, 211-219.
Gullapalli, A., Wolfe, B.L., Griffin, C.T., Magnuson, T. and Trejo, J. (2006). An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: Evidence for retromer, Hrs and Tsg101 Independent functions of sorting nexins. Molec. Biol. Cell., 17 (3), 1228-1238.
Kalantry, S. and Magnuson, T. (2006). The polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation. PLoS Genetics, 2 (5), 656-664.
Bultman, S.J., Gebuhr, T.C., Pan, H., Svoboda, P., Schultz, R.M. and Magnuson, T. (2006). Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev., 20, 1744-1754.
Ciavatta, D., Kalantry, S., Magnuson, T., and Smithies, O. (2006). A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. Proc. Natl. Acad. Sci. USA 103, 9958-9963.
in defective XCI. The 
modify histones, a second evolutionarily conserved mechanism that
modulates chromatin structure is carried out by SWI/SNF and a variety
of other ATPase complexes. SWI/SNF does not possess significant
DNA binding ability of its own but is recruited to promoters by
sequence-specific transcription factors. The energy derived from
ATP hydrolysis allows the complex to alter the conformation and
position of nucleosomes. DNA-histone contacts are broken, and histone
octamers can be slid several hundred base pairs upstream or downstream.
As a result, a core promoter can be made nucleosome-free and accessible
to the RNA Polymerase II holoenzyme so transcription can be initiated.
However, SWI/SNF can be recruited to other loci by transcriptional
repressors and have the opposite effect by inhibiting transcription.
SWI/SNF complexes have been shown to work in concert with HAT complexes.
The lab is using various genetic tools to understand the biological
significance of these complexes in development and human disease
susceptibility.
morphogenetic
and inductive events that define the axes of symmetry at early
stages of embryogenesis. Once the primary axes have been established
further developmental processes lead to the regionalization of
the embryo. Among mammals, mice are the preferred species for genetic
and embryological studies and our lab has developed methods for
manipulating the early mouse embryo. For example, to gain insight
into the morphogenetic role played by the visceral endoderm in
the generation of anterior neural structures we conducted a morphological
and lineage analysis of visceral endoderm cells at pre- and post-primitive
streak stages. Our results shows that a specific group cells, which
are thought to provide signals for the development of the rostral
neurectoderm, have a distinctive morphology and undergo dynamic
positional shifts from the distal tip of the epiblast to the embryonic/extra-embryonic
boundary. These results provide essential tools to study the mechanisms
that shape the mouse embryos at early post-implantation stages
and reveal similarities amongst the extra-embryonic tissues of
developing amniote embryos suggesting that evolutionary conserved
mechanisms pattern the rostral neural structures of vertebrates.
behavioral
components: social deficits, repetitive/ritualistic behavior and
communication abnormalities. There is a wide range of severity
observed in autistic patients as well as the milder, non-clinical
manifestation of the Broader Autism Phenotype (BAP) in family members.
Just as humans can span the range of autistic to BAP to reserved
to outgoing, various inbred lines of mice exhibit a range of different
behaviors. We are examining the social behaviors, cognitive flexibility.
Social communication and brain-specific gene expression patterns
of a variety of inbred strains are being analyzed in order to begin
to dissect the complex trait of autism. 
component of a trafficking
complex called the retromer (see adjacent figure). The evolutionary
conservation of retromer homologs and experiments on their binding
interactions suggest mammals may have similar complexes, but their
biological role is unknown. It is also unclear whether SNX1 and
SNX2 function within a single complex or separate complexes. We
are using genetic approaches in mouse to understand the functional
relationship between the complex members and the significance of
the complex in development and disease.