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Leslie Lange, PhD
Research Assistant Professor


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Research Interests
Genetics of complex diseases, genetics of chronic inflammation, cardiovascular disease, asthma.

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Publications
Weg JG, Anzueto A, Balk RA, Wiedemann HP, Pattishall EN, Schork MA, Wagner LA (1998) The relation of pneumothorax and other air leaks to mortality in the acute respiratory distress syndrome. New England Journal of Medicine 338: 341-346.

Longo KM, Cowen ME, Flaum MA, Valsania P, Schork MA, Wagner LA, Prager RL (1998) Preoperative predictors of cost in medicare-age patients undergoing coronary bypass grafting. Annals of Thoracic Surgery 66: 740-745.

Cabrera CL, Wagner LA, Schork MA, Bohr DF, Cohan BE (1999) Intraocular pressure measurement in the conscious rat. Acta Ophthalmologica Scandinavica 77: 33-36.

Starnes SL, Wolk SW, Lampman RM, Shanley CJ, Prager RL, Kong BK, Fowler JJ, Page JM, Babcock SL, Lange LA, Erlandson EE, Whitehouse WM (1999) Non-invasive evaluation of hand circulation prior to radial artery harvest for coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery 117: 261-266.

Dixit PS, Ghezzi EM, Wagner-Lange LA, Ship JA (1999) The influence of hypothyroidism and thyroid replacement therapy on stimulated parotid flow rates. Journals of Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 87: 55-60.

Kreske ED, Wolk SW, Shanley CJ, Lampman RM, Knake JE, Lange LA, Erlandson EE, Whitehouse WM (1999) Duplex ultrasonography to predict internal cartoid artery stenoses exceeding 50% and 70% as defined by NASCET: The need for multiple criteria. Vascular Surgery 33: 497-506.

Ghezzi EM, Wagner-Lange LA, Schork MA, Metter EJ, Baum BJ, Streckfus CF, Ship JA (2000) Longitudinal influence of menopause and hormone replacement therapy on parotid flow rates in healthy women. Journals of Gerontology: Medical Sciences 55A: M34-42.

Ghezzi EM, Lange LA, Ship JA (2000) Determination of variation of stimulated salivary flow rates. Journal of Dental Research 79(11):1874-8.

Flaherty KR, Kazerooni EA, Curtis JL, Iannettoni M, Lange L, Schork MA, Martinez FJ. (2001) Short-term and long-term outcomes after bilateral lung volume reduction surgery: prediction by quantitative CT. Chest 119(5):1337-46.

Lange LA, Lange EM, Bielak LF, Langefeld CD, Kardia SL, Turner SL, Sheedy PF, Boerwinkle E, Peyser PA. (2002) Autosomal genome-wide scan for coronary artery calcification loci. Arteriosclerosis, Thrombosis and Vascular Biology 22:418-423.

Lange LA, Bowden DW, Langefeld CE, Wagenknecht LE, Carr JJ, Rich SS, Riley WA, Freedman BI. (2002) Heritability of carotid artery intimal medial thickness in type 2 diabetes. Stroke 33(7):1876-1881.

Bensen JT, Lange LA, Langefeld CD, Chang BL, Bleecker ER, Meyers DA, Xu J. (2003) Exploring Pleiotropy using Principal Components. BMC Genet In Press.

Hokanson JE, Langefeld CD, Mitchell BD, Lange LA, Goff Jr. DC , Haffner SM, Saad MF, Rotter JI. Pleiotrophy and heterogeneity in the expression of atherogenic lipoproteins: The IRAS Family Study. Human Heredity 55(1):46-50.

Saluja M, Johnson K, Bhat S, Lange LA, Holzman L, McCune WJ. (2003) Class V lupus nephritis: correlation of membranous glomerular ultrastructural changes with disease severity and outcome. (submitted).

Lange LA, Bowden DW, Langefeld CD, Wagenknecht LE, Beck SR, Brosnihan B, Rich SS, Freedman BI, Herrington D. (2003) Heritability of C-reactive protein in type 2 diabetes. (submitted).

Lange LA, Norris J, Langefeld CD, Wagenknecht LE, Saad MF, Bowden DW. (2003) Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS Family study. (submitted).


ABSTRACTS

Jacobson PA, Ratanatharathorn V, Ma M, Scalzo A, Wagner L, Schork MA, Silver SM, Adams PT, Uberti JP (1997) Risk-adjusted dose schedule of ganciclovir is effective for the prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients. Blood 90: 4410.

Cabrera CL, Wagner LA, Schork MA, Bohr DF, Cohen BE (1997) Intraocular pressure measurement in the conscious rat. Investigative Ophthalmology and Visual Science 38: 797.

Giba EM, Wagner LA, Schork MA, Ship JA. Longitudinal influence of age and medication on parotid flow rates. (1997) Gerontological Society of America Meeting, Cincinnati, OH, Nov. 1997.

Eagle KA, Sievers JJ, Bolling SF, Pagani FD, Schork MA, Wagner LA, Deeb GM. (1997) Risk adjustment in coronary surgery: Comparison of validated models in a high risk cohort. American Heart Association, 70th Scientific Sessions.

Cohan BE, Wagner LA, Schork MA, Bohr DF (1997) Rat intraocular pressure nonresponse to corticosteroid. Investigative Ophthalmology and Visual Science 38: 798.

Bohr DF, Wagner-Lange LA, Schork MA, Cohan BE (1998) Intraocular pressure circadian rhythm in rats is stain-specific. Investigative Ophthalmology and Visual Science 39: S486.

Ghezzi EM, Wagner LA, Schork MA, Ship JA (1998) Longitudinal influence of age, medications and gender on parotid output. Journal of Dental Research. 77: 1400.

Lange LA, Kardia SLR, Bielak LF, Turner ST, Boerwinkle E, Sheedy PF, Peyser PA (2000) Coronary artery calcification is associated with two polymorphisms in the beta-2 adrenergic receptor gene. American Society of Human Genetics 50th Annual Meeting. San Diego, CA.

Lange LA, Lange EM, Bielak LF, Langefeld CD, Kardia SL, Turner ST, Sheedy PF, Boerwinkle E, Peyser PA (2001) Autosomal genomewide linkage scan for coronary artery calcification loci. American Heart Association 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevention. San Antonio, Texas.

Lange LA, Wagenknecht, LE, Langefeld CD, Freedman BI, Riley WA, Rich SS, Bowden DW. (2001) Familial aggregation of cardiovascular disease risk factors in type 2 biabetic families. American Society of Human Genetics 51st Annual Meeting. San Diego, CA.

Hokanson JE, Langefeld CD, Rotter JI, Lange LA, Haffner SM, Goff DC. (2002) Pleiotropy and heterogeneity in the expression of atherogenic lipoproteins. 42nd Annual Conference on Cardiovascular Disease Epidemiology and Prevention. Honolulu, Hawaii.

Lange LA, Langefeld CD, Beck SR, Rich SS, Herrington DM, Bowden DW. (2003) Familial Aggregation of C-Reactive Protein in Type 2 Diabetes. The 43rd Annual Conference on Cardiovascular Disease Epidemiology and Prevention. Miami, Florida.


jump to research interests jump to publications jump to trainees jump to contact info


jump to research interests jump to publications jump to trainees jump to contact info

Contact Information
Department of Genetics
4312 Medical Biomolecular Research Building, CB 7264
103 Mason Farm Road
Chapel Hill, NC 27599
919.966.9562
Email: leslie_lange<at>med.unc.edu

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