Lange E, Gatti RA, Sobel E, Concannon P, Lange K (1993) How many ataxia-telangiectasia genes? In: Ataxia-telangiectasia. (R.A. Gatti and R.B. Painter, Eds) NATO ASI Series Vol. H 77. Springer-Verlag Berlin Heidelberg. 37-54.

PEER REVIEWED PUBLICATIONS

Zuhlke KA, Madeoy JJ, Dimmer JB, White KA, Griffin A, Lange EM, Gruber SB, Ostrander EA, Cooney KA (2004) Truncating BRCA1 mutations are uncommon in hereditary prostate cancer families with evidence of linkage to 17q markers. Clinical Cancer Research (in press).

Lange EM, Boehnke M (2004) The haplotype runs test: The parent-parent-affected-offspring trio design. Genetic Epidemiology (in press).

Gillanders EM, Xu J, Chang B, Lange EM, Wiklund F, Bailey-Wilson JE, Baffoe-Bonnie A, Jones MP, Gildea D, Riedesel E, Albertus J, Isaacs SD, Wiley KE, Mohai CE, Matikainen MP, Tammela TLJ, Zheng SL, Brown WM, Rokman A, Meyers DA, Schleutker J, Gronberg H, Cooney KA, Isaacs WB, Trent JM (2004) Combined genome-wide scan for prostate cancer susceptibility genes in four hereditary prostate cancer populations: evidence for linkage at 17q22. Journal of the National Cancer Institute (in press)

Blumenthal MN, Langefeld CD, Beaty TH, Bleecker ER, Ober C, Lester L, Lange E, Barnes KC, Wolf R, King RA, Solway J, Oetting W, Meyers DA, Rich SS for the NHLBI Collaborative Study on the Genetics of Asthma (2004) A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma (CSGA). Human Genetics 114:157-164.

Ambrosius WT, Lange EM, Langefeld CD (2004) Power for genetic association studies with random allele frequencies and genotype distributions. American Journal of Human Genetics 74: 683-693.

Lange EM, Lange K (2004) Powerful allele-sharing statistics for nonparametric linkage analysis. Human Heredity 57:49-58.

Brown WM, Lange EM, Chen H, Xu J, Isaacs WB, Cooney KA (2004) Hereditary prostate cancer in African American families: Linkage analysis using markers that map to five candidate susceptibility loci. British Journal of Cancer 90:510-514.

Brown WM, Beck SR, Lange EM, Davis CC, Kay CM, Langefeld CD, Rich SS, Framingham Heart Study (2003) Age-stratified heritability estimation in the Framingham families. BMC Genetics 4:S32.

Lange EM, Gillanders EM, Davis CC, Brown WM, Cambpell JK, Jones M, Gildea D, Riedesel E, Albertus J, Freas-Lutz D, Markey C, Giri V, Dimmer JB, Montie JE, Trent JM, Cooney KA (2003) Genome-wide linkage scan for prostate cancer susceptibility genes using families from the University of Michigan Prostate Cancer Genetics Project finds evidence for linkage on chromosome 17 near BRCA1. The Prostate 57:326-334.

Miller DC, Zheng SL, Dunn RL, Sarma AV, Lange EM, Meyers DA, Xu J, Cooney KA (2003) Germline mutations of the macrophage scavenger receptor 1 gene: Association with prostate cancer risk in African-American men. Cancer Research 63:3486-3489.

Huang S-K, Mathias RA, Ehrlich E, Plunkett B, Liu X, Cutting GR, Wang XJ, Li XD, Togias A, Barnes KC, Malveaux F, Rich S, Mellen B, Lange E, Beaty TH, and the CSGA (2003) Evidence for asthma susceptibility genes on chromosome 11 in an African American population. Human Genetics 113:71-75.

Colilla S, Nicolae D, Pluzhnikov A, Blumenthal MN, Beaty TH, Bleecker ER, Lange EM, Rich SS, Meyers DA, Ober C, Cox NJ, and the CSGA (2003) Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. Journal of Allergy and Clinical Immunology 111:840-846.

Chen H, Griffin A, Wu Y-Q, Tomsho LP, Zuhlke KA, Lange EM, Gruber SB, Cooney KA (2003) RNASEL mutations in hereditary prostate cancer. Journal of Medical Genetics 40:e21.

Hirakawa S, Lange EM, Colicigno CJ, Freedman BI, Rich SS, Bowden DW (2003) Evaluation of genetic variation and linkage disequilibrium in the matrix metalloproteinase 9 gene, MMP9, in end stage renal disease patients. American Journal of Kidney Diseases 42:133-142.

Smith TR, Miller MS, Lohman K, Lange EM, Case LD, Mohrenweiser HW, Hu JJ (2003) Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Letters 190: 183-190.

Mahadev K, Raval G, Bharadwaj S, Willingham MC, Lange EM, Vonderhaar B, Salomon D, Prasad GL (2002) Suppression of the transformed phenotype of breast cancer by tropomyosin-1. Experimental Cell Research 279: 40-51.

Xu J, Zheng SL, Komiya A, Mychaleckly J, Isaacs SD, Hu JJ, Sterling D, Lange EM, Hawkins GA, Turner A, Ewing CM, Faith DA, Johnson JR, Suzuki H, Piroska B, Wiley KE, DeMarzo A, Bova GS, Chang B, Hall MC, McCullough DL, Partin AW, Kassabian VS, Carpten JD, Bailey-Wilson J, Trent JM, Ohar J, Bleeker ER, Walsh PC, Isaacs WB, Meyers DA (2002) Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nature Genetics 32: 321-325.

Guo S-W, Jenisch S, Stuart P, Lange EM, Kukuruga D, Nair RP, Henseler T, Voorhees JJ, Christophers E, Elder JT (2002) Combined segregation and linkage analysis of HLA markers in familial psoriasis. European Journal of Human Genetics 10: 327-333.

Shah S, Doyle K, Lange EM, Shen P, Pennell T, Ferree C, Levine EA, Perrier ND (2002) Breast cancer recurrences in elderly patients after lumpectomy. The American Surgeon 68: 735-739.

Lange LA, Lange EM, Bielak LF, Langefeld CD, Kardia SL, Turner SL, Sheedy PF, Boerwinkle E, Peyser PA (2002) Autosomal genome-wide scan for coronary artery calcification loci in sibships at high risk for hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology 22: 418-423.

Mohlke KL, Lange EM, Valle TT, Ghosh S, Magnuson VL, Silander K, Watanabe RM, Chines PS, Bergman RN, Tuomilehto J, Collins FS, Boehnke M (2001) Linkage disequilibrium between microsatellite markers extends beyond 1 cM on Chromosome 20 in Finns. Genome Research 11: 1221-1226.

Davis CC, Brown WM, Lange EM, Rich SS, Langefeld CD (2001) Nonparametric linkage regression II: Identification of influential pedigrees in tests for linkage. Genetic Epidemiology 21: S123-S129.

Bock CH, Cunningham JM, McDonnell SK, Schaid DJ, Peterson BJ, Pavlic RJ, Schroeder JJ, Klein J, French AJ, Marks A, Thibodeau SN, Lange EM, Cooney KA (2001) Analysis of the prostate cancer susceptibility locus HPC20 in 172 prostate cancer families. American Journal of Human Genetics 68: 795-801.

Watanabe RM, Ghosh S, Langefeld CD, Valle T, Hauser ER, Magnuson VL, Mohlke KL, Silander K, Ally DS, Blaschak-Harvan J, Douglas JA, Duren WL, Epstein MP, Fingerlin TE, Kaleta H-S, Lange EM, Li C, McEachin RC, Stringham HM, Trager E, White PP, Balow J, Birznieks G, Chang J, Chines P, Eldridge W, Erdos MR, Karanjawala ZE, Knapp JI, Kudelko K, Martin C, Morales-Mena A, Musick A, Musick T, Pfahl C, Porter R, Raymon JB, Rha D, Segal L, Shapiro S, Sharaf R, Shurtleff B, So A, Tannenbaum J, Tovar J, Te C, Unni A, Welch C, Whiten R, Witt A, Kohtamaki K, Eriksson J, Toivanen L, Vidgreen G, Nylund SJ, Tuomilehto-Wolf E, Ross EH, Demirchyan E, Hagopian WA, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M (2000) The Finland-United States Investigation of Non-Insulin Dependent Diabetes Mellitus (FUSION) genetic study: II. An autosomal genome scan for quantitative trait loci. American Journal of Human Genetics 67: 1186-1200.

Gosh S, Watanabe RM, Valle T, Hauser ER, Magnuson VL, Langefeld CD, Ally DS, Mohlke KL, Silander K, Kohtamaki K, Chines P, Barlow J, Birznieks G, Chang J, Eldridge W, Erdos MR, Karanjawala ZE, Knapp JI, Kudelko K, Martin C, Morales-Mena A, Musick A, Musick T, Pfahl C, Porter R, Raymon JB, Rha D, Segal L, Shapiro S, Sharaf R, Shurtleff B, So A, Tannenbaum J, Te C, Tovar J, Unni A, Whiten R, Witt A, Blaschak-Harvan J, Douglas JA, Duren WL, Epstein MP, Fingerlin TE, Kaleta H-S, Lange EM, Li C, McEachin RC, Stringham HM, Trager E, White PP, Eriksson J, Toivanen L, Vidgren G, Nylund SJ, Tuomilehto-Wolf E, Ross EH, Demirchyan E, Hagopian WA, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M (2000) The Finland-United States Investigation of Non-Insulin Dependent Diabetes Mellitus (FUSION) genetic study: I. An autosomal genome scan for genes that predispose to type 2 diabetes. American Journal of Human Genetics 67: 1174-1185.

Lange EM, Chen H, Brierley K, Livermore H, Wojno KJ, Langefeld CD, Lange K, Cooney KA (2000) The polymorphic exon 1 androgen receptor CAG repeat in men with a potential inherited predisposition to prostate cancer. Cancer Epidemiology, Biomarkers & Prevention 9: 439-442.

Xu J and International Consortium for Prostate Cancer Genetics (ICPCG)* (Lange EM first author from University of Michigan group) (2000) Combined analysis of hereditary prostate cancer linkage to 1q24-25: Results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics. American Journal of Human Genetics 66: 945-957.

Lange EM, Chen H, Brierley K, Perrone E, Bock CH, Gillanders E, Ray ME, Cooney KA (1999) Linkage analysis of 153 prostate cancer families over a 30cM region containing the putative susceptibility locus HPCX. Clinical Cancer Research 5: 4013-4020.

Cerosaletti KM, Lange E, Stringham HM, Weemaes CMR, Smeets D, Solder B, Belohradsky BH, Taylor AMR, Karnes P, Elliott A, Komatsu K, Gatti RA, Boehnke M, Concannon P (1998) Fine localization of the Nijmegen breakage syndrome gene to 8q21: Evidence for a common founder haplotype. American Journal of Human Genetics 63: 125-134.

Cooney KA, McCarthy JD, Lange E, Huang L, Miesfeldt S, Montie JE, Oesterling JE, Sandler HM, Lange K (1997) Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. Journal of the National Cancer Institute 89: 955-959.

Xia Y-R, Welch CL, Warden CH, Lange E, Fukao T, Lusis AJ, Gatti RA (1996) Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse chromosome 9. Mammalian Genome 7: 554-555.

Lange E, Borresen A-L, Chen X, Chessa L, Chiplunkar S, Concannon P, Dandekar S, Gerken S, Lange K, Liang T, McConville C, Polakow J, Porras O, Rotman G, Sanal O, Sheikhavandi S, Shiloh Y, Sobel E, Taylor M, Telatar M, Teraoka S, Tolun A, Udar N, Uhrhammer N, Vanagaite L, Wang Z, Wapelhorst B, Yang H-Y, Yang L, Ziv Y, Gatti RA (1995) Localization of an ataxia-telangeictasia gene to an ~500 kb interval on chromosome 11q23.1: Linkage analysis of 176 families by an international consortium. American Journal of Human Genetics 57: 112-119.

Uhrhammer N, Lange E, Porras O, Naiem A, Chen X, Sheikhavandi S, Chiplunkar S, Yang L, Dandekar S, Liang T, Patel N, Teraoka S, Udar N, Calvo N, Concannon P, Lange K, Gatti RA (1995) Sublocalization of an ataxia-telangiectasia gene distal to D11S384 by ancestral haplotyping in Costa Rican families. American Journal of Human Genetics 57: 103-111.

Nair RP, Guo S-W, Jenisch S, Henseler T, Lange EM, Terhune M, Westphal E, Christophers E, Voorhees JJ, Elder JT (1995) Scanning chromosome 17 for psoriasis susceptibility: Lack of evidence for a distal 17q locus. Human Heredity 45: 219-230.

Telatar M, Lange E, Uhrhammer N, Gatti RA (1995) New localization of NCAM, proximal to DRD2 at chromosome 11q23. Mammalian Genome 6: 59-60.

Gatti RA, Lange E, Rotman G, Chen X, Uhrhammer N, Liang T, Chiplunkar S, Yang L, Udar N, Dandekar S, Sheikhavandi S, Wang Z, Yang H-M, Polakow J, Elashoff M, Telatar M, Sanal O, Chessa L, McConville C, Taylor M, Shiloh Y, Porras O, Borresen A-L, Wegner R-D, Curry C, Gerken S, Lange K, Concannon P (1994) Genetic haplotyping of ataxia-telangeictasia families localize the major gene to an ~850 kb region on chromosome 11q23.1. International Journal of Radiation Biology 66: S57-S62.

Gatti RA, Peterson KL, Novak J, Chen X, Yang-Chen L, Liang T, Lange E, Lange K (1993) Prenatal genotyping of ataxia-telangiectasia. The Lancet 342: 376.

Johnson B, Brooks BA, Heinzmann C, Diep A, Mohandas T, Sparkes R, Reyes H, Hoffman E, Lange E, Gatti RA, Xia Y-R, Lusis AJ, Hankinson O (1993) The ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse Chromosome 3 near CF-3. Genomics 17: 592-598.

Sobel E, Lange E, Jaspers NGJ, Chessa L, Sanal O, Shiloh Y, Taylor AMR, Weemaes CMA, Lange K, Gatti RA (1992) Ataxia-telangiectasia: Linkage evidence for genetic heterogeneity. American Journal of Human Genetics 50: 1343-1348.
Sanal O, Lange E, Telatar M, Sobel E, Salazar-Novak J, Ersoy F, Morrison A, Concannon P, Tolun A, Gatti RA (1992) Ataxia-telangiectasia: Linkage analysis of chromosome 11q22-23 markers in Turkish families. FASEB 6: 2848-2852.

Ziv Y, Frydman M, Lange E, Zelnik N, Rotman G, Julier C, Jaspers NGJ, Dagan Y, Abeliovicz D, Dar H, Borochowitz Z, Lathrop M, Gatti RA, Shiloh Y (1992) Ataxia-telangiectasia: Linkage analysis in highly inbred Arab and Druze families and differentiation from an ataxia-microcephaly-cataract syndrome. Human Genetics 88: 619-626.

Foroud T, Wei S, Ziv Y, Sobel E, Lange E, Chao A, Goradia T, Huo Y, Tolun A, Chessa L, Charmley P, Sanal O, Salman N, Julier C, Concannon P, McConville C, Taylor AMR, Shiloh Y, Lange K, Gatti RA (1991) Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: Linkage analysis of 111 families by an international consortium. American Journal of Human Genetics 49: 1263-1279.

MANUSCRIPTS SUBMITTED FOR PEER REVIEW

Wu J, McCrory MA, Fenglong X, Fan Z-Q, Zakharkin SO, George V, Lange EM, Langefeld CD,Allison DB, Cooper GS, Kimberly RP, Szalai AJ (2004) Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene influence promoter activity and associate with serum CRP. (submitted)

Kritchevsky SB, Nicklas BJ, Visser M, Simonsick EM, Newman AB, Harris TB, Lange EM, Penninx BW, Goodpaster BH, Satterfield S, Colbert L, Rubin SM, Pahor M (2004) Angiotensin converting enzyme insertion/deletion genotype, exercise and physical decline: Evidence of a gene-environment interaction. (submitted)

Schaid DJ, Chang BL and The International Consortium for Prostate Cancer Genetics (EM Lange first author from Michigan Group) (2004) Description of the International Consortium for Prostate Cancer Genetics, and failure to replicate linkage of hereditary prostate cancer to 20q13. (submitted)

INVITED REVIEWS

Cooney KA, Lange E, Lange K (1997) Re: Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. Journal of the National Cancer Institute 89: 1894.

INVITED PRESENTATIONS AT NATIONAL MEETINGS (PEER SELECTED)

Lange EM (December 1998) Analysis of potential HPC loci on the X chromosome in hereditary prostate cancer families. American Association for Cancer Research Special Conference, “New Approaches in the Prevention and Cure of Prostate Cancer”. Palm Springs, California.

Lange E (October 1998) A novel approach for identification of common ancestral haplotypes associated with complex phenotypes. American Society of Human Genetics. Denver, Colorado.