Beverly H Koller | Department of Genetics

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Beverly H Koller, PhD
Associate Professor

Research Interests
Key words: mouse models for human diseases, genes that modify disease progression

Our lab is using the recently developed technique known as gene targeting to create animal mouse models for human diseases and to identify genes that modify the progress of these diseases. The technique of gene targeting, which allows us to introduce specific changes into the genomes of experimental animals, relies on recent advances in the fields of homologous recombination and embryonic stem (ES) cell technology. The first step in this procedure, once the gene to be modified has been chosen, is to obtain corresponding genomic DNA sequences using stardard cloning techniques. After introducing desired mutations into the cloned DNA using conventinal molecular biology techniques, the genomic sequences are incorporated into a plasmid known as a targeting vector. When this plasmid is introduced into mouse ES cells, the altered genomic sequences are able to undergo homologous recombination with the corresponding endogenous sequences, thereby inroducing the desired modifications into the moust genome. ES cells are unique in that they can be grown in tissue culture while maintaining their totipotency. Thus, one ES cells carrying the desired mutation are identified, they can be returned to an embryo, resulting in the formation of a chimeric animal. If the embryonic stem cells participate in the formation of the germ line of the chimeric animal. the mutation will be transmitted to the chimera's offspring, and a mouse line carrying the desired mutation will be created. The effect of this alteration can then be studied in vivo. This technology has opened an exciting new avenue for addressing numerous biological and medical problems.

We have used gene targeting to generate an animal model for the most common genetic disease n the Caucasian population, cystic fibrosis. We are continuing to characterize this animal and to modify it to produce a disease that more closely resembles human cystic fibrosis. A second area in which our lab is interested involves the study of the inflammatory processes involved in allergic responses, asthma, and arthritis. Our current efforts are aimed at generating animals deficient in various factors that are believed to be important in these diseases. By providing us with a better understanding of the immunological processes that underlie allergic responses, asthma and arthritis, these animals should help us to identify more effective treatments for these diseases.

Publications
Koller, B.H., B. Dunlap, J. Hank, S.L. Wee, and F.H. Bach. Family of large surface proteins on human lymphocytes. Scand. J. Immunol. 12:525, 1980.

Dunlap, B., P.F. Mixter, B. Koller, A. Watson, M.B. Widmer, and F.H. Bach. Molecular relationships between large membrane proteins (LMP) expressed on T and B lymphocytes. J. Immunol. 125:1829, 1980

Dunlap, B., B. Koller, J. Hank, M.B. Widmer, and F.H. Bach. Differences in cell surface phenotype of functionally disparate cloned T cells. Trans. Proc. XIII:1143, 1981

Bach, F.H., B.J. Alter, B. Dunlap, B. Koller, C. Orosz, N. Roehm, and M.B. Widmer. Allo-responsive T lymphocytes and their differentiation markers. Fed. Proc. 40:1466, 1981

LeBien, T., J.G. Bradley, and B. Koller. Preliminary structural characterization of the leukocyte cell surface molecule recognized by monoclonal antibody TA 1. J. Immunol. 130:1833-1836, 1983

Koller, B.H., and H.T. Orr. Cloning and complete sequence of an HLA-A2 gene: Analysis of two HLA-A alleles at the nucleotide level. J. Immunol. 134:2727-2733, 1985

Koller, B.H., F.E. Ward, R. DeMars, and H.T. Orr. Comparison of multiple HLA-A alleles at the DNA level by using Southern blotting and HLA-A specific probes. J. Immunol. 135:4229-4234, 1985

Shimizu, Y., B. Koller, D. Geraghty, H. Orr, Yoji Shimizu, and Robert DeMars. Transfer of cloned human class I MHC genes into HLA-mutant human lymphoblastoid cells. Mol. Cell Biol. 6:1074-1087, 1986

Carroll, M. C., P. Katzman, E. M. Alicot, B. H. Koller, D. E. Geraghty, H. T. Orr, J. L. Strominger, and T. Spies. Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes. Proc. Natl. Acad. Sci. USA 84:8535-8539, 1987

Geraghty, Daniel E., Beverly H. Koller, and Harry T. Orr. A human major histocompatibility complex I gene that encodes a protein with a shortened cytoplasmic segment. Proc. Natl. Acad. Sci. USA 84:9145-9149, 1987

Shimizu, Yoji, Daniel E. Geraghty, Beverly H. Koller, Harry T. Orr, and Robert Demars. Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 85:227-231, 1988

Koller, Beverly H., Daniel E. Geraghty, Yoji Shimizu, Robert DeMars and Harry T. Orr. HLA-E: A novel HLA class I gene expressed in resting T lymphocytes. J. Immunol. 141:897-904, 1988

Mizano, S., J. A. Trapani, B. H. Koller, B. Dupont, S. Y. Yang. Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene. J. Immunol. 140:4024-4030, 1988.

Koller, Beverly H., Daniel E. Geraghty, Robert DeMars, Lisa Duvick, Stephen S. Rich, and Harry T. Orr. Chromosomal organization of the human major histocompatibility complex class I gene family. J. Exp. Med. 169:469-480, 1989.

Uckun, Faith M., Atsushi Muraguchi, Jeffrey A. Ledbetter, Tadamitsu Kishimoto, Richard T. O'Brien, James S. Roloff, Kazimiera Gajl-Peczalska, Arthur Provisor, and Beverly Koller. Biphenotypic leukemic lymphocyte precursors in CD2+Cd19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues. Blood 73:1000-1015, 1989.

Koller, Beverly H., Lora J. Hagemann, Thomas Doetschman, John R. Hagaman, Shiu Huang, Phillip J. Williams, Neal L. First, Nobuyo Maeda, and Oliver Smithies. Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proc. Natl. Acad. Sci. USA 86:8927-8931, 1989.

Koller, Beverly H. and Oliver Smithies. Inactivating the ?2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc. Natl Acad. Sci. USA 86:8932-8935, 1989.

Geraghty, Daniel E., X. H. Wei, Harry T. Orr, and Beverly H. Koller. Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetative element. J. Exp. Med. 171:1-18, 1990.

Reid, L., R. Gregg, O. Smithies, and B. H. Koller. Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells. Proc Natl. Acad. Sci. USA 87:4299-4303, 1990.

Koller, Beverly H., Philippa Marrack, John W. Kappler, and Oliver Smithies. Normal development of mice deficient in ß2M, MHC Class I proteins, and CD8+ T Cells. Science 248:1227-1230, 1990.

Höglund, Petter, Claes Öhlen, Ennio Carbone, Lars Franksson, Hans-Gustaf Ljunggren, Ann Latour, Beverly Koller, and Klas Kärre. Recognition of ?2-microglobulin-negative (?2m-/-) T-cell blasts by natural killer cells from normal but not from ß2m- mice: Nonresponsiveness controlled by ?2m-/- bone marrow in chimeric mice. Proc. Natl. Acad. Sci. USA 88:10332-10336, 1991.

Koller, Beverly H., Hyung-Suk Kim, Anne M. Latour, Kristen Brigman, Richard C. Boucher, Jr., Peter Scambler, Brandon Wainwright, and Oliver Smithies. Toward an animal model of cystic fibrosis: Targeted interruption of exon 10 of cystic fibrosis transmembrane regulator gene in embryonic stem cells. Proc. Natl. Acad. Sci. USA 88:10730-10734, 1991.

Muller, Daniel, Beverly H. Koller, J. Lindsay Whitton, Katherine E. LaPan, Kristen K. Brigman, and Jeffrey A. Frelinger. LCMV-specific, Class II-restricted cytotoxic T cells in ?2-microglobulin-deficient mice. Science 255:1576-1578, 1992.

Tarleton, R. L., B. H. Koller, A. Latour, and M. Postan. Susceptibility of ?2-microglobulin-deficient to Trypanosoma cruzi infection. Nature 356:338-340, 1992.

Markmann J. F., H. Bassiri, N. M. Desai, J. S. Odorico, J. I. Kim, B. H. Koller, O. Smithies, and C. F. Barker. Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation 54: 1085-1089, 1992

Flynn J. L., M. M. Goldstein, K. J. Triebold, B. Koller, and B. R. Bloom. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA 89: 12013-12017, 1992.

Glas R., L. Franksson, C. Ohlen, P. Hoglund, B. Koller, H. G. Ljunggren, and K. Karre. Major histocompatibility complex class I-specific and -restricted killing of ? 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 89: 11381-11385, 1992.

Geraghty D. E., B. H. Koller, J. Pei, and J. A. Hansen-J-A. Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. J. Immunol. 149:1947-1956, 1992.

Geraghty D. E., B. H. Koller, J. A. Hansen, and H. T. Orr. The HLA class I gene family includes at least six genes and twelve pseudogenes and gene fragments. J. Immunol. 149:1934-1946, 1992.

Rajan T. V., F. K. Nelson, L. D. Shultz, B. H. Koller, and D. L. Greiner. CD8+ T lymphocytes are not required for murine resistance to human filarial parasites. J. Parasitol. 78:744-746, 1992.

Spriggs, M. K., B. H. Koller, T. Sato, P. J. Morrissey, W. C. Fanslow, O. Smithies, R. F. Voice, M. B. Widmer, and C. R. Maliszewski. Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc. Natl. Acad. Sci. U S A 89:6070-6074, 1992.

Clarke, Lane L., Barbara R. Grubb, Sheriv E. Gabriel, Oliver Smithies, Beverly H. Koller, and Richard C. Boucher. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science 257:1125-1128, 1992.

Snouwaert, John N., Kristen K. Brigman, Anne M. Latour, Nadia M. Malouf, Richard C. Boucher, Oliver Smithies, and Beverly H. Koller. An animal model for cystic fibrosis made by gene targeting. Science 257:1083-1088, 1992.

Desai, N. M., H. Bassiri, J. S. Odorico, B. H. Koller, O. Smithies, A. Naji, C. F. Barker, and J. F. Markmann. Pancreatic islet allograft and xenograft survival in CD8+ T-lymphocyte-deficient recipients. Transplant Proc. 25:961-962, 1993.

Desai, N. M., H. Bassiri, J. Kim, B. H. Koller, O. Smithies, C. F. Barker, A. Naji, and J. F. Markmann. Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice. Transplantation 55:718-722, 1993.

Coffman, T., S. Geier, S. Ibrahim, R. Griffiths, R. Spurney, O. Smithies, B. Koller, and F. Sanfilippo. Improved renal function in mouse kidney allografts lacking MHC class I antigens. J. Immunol. 151:425-435, 1993.

Dombrowicz, D., V. Flammand, K. K. Brigman, B. H. Koller, and J.-P. Kinet. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor * chain gene. Cell 75:969-976, 1993.

Gabriel, S. E., K. N. Brigman, B. H. Koller, R. C. Boucher, and M. J. Stutts. Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model. Science 266:107-109.1994

Goulet, J. L., J. N. Snouwaert, A. M. Latour, T. M. Coffman, and B. H. Koller. Altered inflammatory responses in leukotriene-deficient mice. Proc. Natl. Acad. Sci. USA 91:12852-1252.1994.

Roach, M.L., J.L. Stock, R. Byrum, B.H. Koller, and J.D. McNeish. A new embryonic stem cell line from DBA/11ac mice allows genetic modification in a murine model of human inflammation. Experimental Cell Res. 221:153-156, 1995.

Engel, P., L.J. Zhou, D.C. Ord, S. Sato, B. Koller, and T.F. Tedder. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signaltransduction molecule. Immunity 3:39-50, 1995.

Ohlen, C., P. Hoglund, C.L. Sentman, E. Carbone, H.G. Ljunggren, B. Koller, and K. Karre. Inhibition of natural killer cell-mediated bone marrow graft rejection by allogeneic major histocompatibility complex class I, but not class II molecules. Eur. J. Immunol. 25:1286-91, 1995.

Snouwaert, J.N., K.K. Brigman, A.M. Latour, E. Iraj, U. Schwab, M.I. Gilmour, and B.H. Koller. A murine model of cystic fibrosis. J. Respir. Crit. Care Med. 151:S59-S64, 1995.

Gowen, L.C., B.L. Johnson, A.M. Latour, K.K. Sulik, and B.H. Koller. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet. 12:191-194, 1996.

Voelkel, N.F., R.M. Tuder, K. Wade, M. Hoper, R.A. Lepley, J.L. Goulet, B.H. Koller, and F. Fitzpatrick. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. J. Clin. Invest. 97:2491-2498, 1996.

Dombrowicz, D., A.T. Brini, V. Flamand, E. Hicks, J.N. Snouwaert, J-P. Kinet and B.H. Koller. Anaphylaxis Mediated through a Humanized High Affinity IgE Receptor. J. Immunol. 157:1645-1651, 1996.

Stanford, W.L., S. Haque, R. Alexander, X. Liu, A.M. Latour, H.R. Snodgrass, B.H. Koller and P. Flood. Altered proliferative response by T lymphocytes of Ly-6S (Sca-1) null mice. J Exp. Med. 186: 705-17.

Griffiths,R. J., M.A. Smith, M.L.Roach, J.L. Stock, E.J. Stam, A.J. Milici, D.N.Scampoli, J.D. Eskra, R.S. Byrum, B.H. Koller and J.D. McNeish. Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice. J. Exp. Med. 185:1123-9.

Byrum, R.S., J.L. Goulet, R.J. Griffiths, and B.H. Koller. Role of the 5-lipoxygenase activating protein (FLAP) in murine acute inflammatory responses. J. Exp. Med. 185: 1065 1997.

Mohn, A.R., R.M. Feddersen, M.S. Nguyen, and B.H. Koller. Phenotypic analysis of mice lacking the highly abundant purkinje cell- and bipolar neuron-specific PCP2 protein. Mol. Cell. Neurosci. 9:63-76, 1997.

Goulet, J.L., C-Y Wang, and B.H. Koller. Embryonic stem cell lines from MRL mice allow genetic modification in a murine model of autoimmune disease. J. Immunol. 159:4376-4381,1997.

Nguyen, M., T. Camenisch, J.N. Snouwaert, E. Hicks, T.M. Coffman, P.A.W. Anderson, N.N. Malouf, and B.H. Koller. The prostaglandin receptor EP4 triggers remodeling of the cardiovascular system at birth. Nature 390:78-81, 1997.

Dombrowicz,D., Lin S., Flamand, V., Brini, A.T. Koller, B.H., and J-P Kinet. Allergy-associated FcR? is a molecular apmplifer of IgE- and IgG-mediated in vivo responses. Immunity 8:517-529, 1998.

Gowen, L.C., Avrutskaya, A.V., Latour, A.M., Koller, B.H and S.A. Leadon. Brca1 is required for the Transcription-Coupled Repair of Oxidative DNA Damage. Science 281:1009-1012, 1998.

Barker, P.M., Nguyen, M.S., Gatzy, J.T., Grubb, B., Norman, Hilary, Hummler, E., Rossier, B., Boucher, R.C. and B.H. Koller. Role of ?ENaC Subunit in Liquid Clearance and Electrolyte Balance in Newborn Mice. J. Clin. Invest. 102:1634-1640.

Flemming, E.R., Athirakul K, Oliverio, M.I., Key, M, Goulet J., Koller, B.H. and T.M. Coffman. Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2. Am J Physiol, 275: F955-F961 1998.

Thomas, D.W., Mannon, R.B., Mannon, P.J., Latour A., Oliver, J.A., Hoffman, M., Smithies O., Koller, B.H., and T.M. Coffman. Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest, 102,1994-2001,1998.

Cressman, V.L., Hicks, E.M., Funkhouser, W.K., Backlund, D.C. and B.H. Koller. The relationship of chronic mucin secretion to airway disease in normal and CFTR-deficient mice. Am. J. Respir. Cell Mol. Biol., 19 853-866, 1998.

Cressman, V.L., Backlund, D.C., Hicks, E.M., Gowen, L.C., Godfrey, D.V.M., and B.H. Koller. Mammary tumor formation in p53- and BRCA1-deficient mice. Cell Growth and Differentation, 10, 1-10, 1999.

Camenisch, T.D., Koller, B.H., Earp, H.S., and G. K. Matsushima. A novel receptor tyrosine kinase, mer inhibits TNR-a production and lipopolysaccharide-induced endotoxic shock. J. Immunol. 162: 3498-3503, 1999.

Tilley, S.L., Audoly, L.P., Hicks, E.H., Kim, H-S, Flannery, P.J., Coffman, T.M., and B.H. Koller. Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor. J. Clin. Invest. 103: 1539-1545. 1999.

Cressman, V.L., Lazarowski, Eduardo, Homolya, L., Boucher, R.C., Koller, B.H., Grubb, B.R. Effect of P2Y2 receptor gene targeting on nucleotide regulation of murine epithelial Cl- transport. JBC 274: 26461-26468, 1999

Homolya, L., Watt, W.C., Lazarowski, E.R., Koller, B.H., R. Boucher. Nucleotide-regulated calcium signaling in lung fibroblasts and epithelia cells from normal and P2Y2 receptor (-/-) mice. JBC 274: 26454-26460,1999.

Audoly, L.P., Tilley, S.L., Goulet, J., Key, M., M., Nguyen, Stock, J., McNeish, J., Koller, B.H., and T.M. Coffman. Identification of specific EP receptors responsible for the hemodynamic effects of PGE2 Am. J. Physiol. 277: H924-H930. 1999.

Cressman, V.L., Backlund, D.C., Avrutskaya, A.V., Leadon, S.A., Godfrey, V. and B.H. Koller. Growth retardation, DNA repair defects and lack of spermatogenesis in BRCA1 deficient mice. Mol Cell Bio. 19:7061-7075. 1999.

Mohn, A. R, Gainetdinov, R., Caron, M.G. and B.H. Koller. Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia. Cell 98:427-436. 1999.

Itoh-Lindstrom, Y., Piskurich, J.F., Felix, N. J., Wang, Y., Brickey, W. J., Platt, J. L., Koller, B. H., and J. P.-Y. Ting. Reduced IL-4, Lipopolysaccharide, and IFN-?-Induced MHC Class II Expression in Mice Lacking Class II Transactivator Due to Targeted Deletion of the GTP-Binding Domain. J of Immunol., 163; 2425-2431. 1999.

Fabre, J-E, Nguyen, T., Latour, A., Goodman, J., Audoly, L., Coffman, T., and B.H. Koller. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. Nature Medicine 5:1199-1202.1999.

Snouwaert, J. N., Gowen, L. C., Latour, A. M., Mohn, A. R., Xiao, A., DiBiase, L., and B.H. Koller. BRCA1 deficient embryonic stem cells display a decreased homologus recombination frequency and an increased frequency of non-homlogous recombination that is corrected by expression of a Brca1 transgene. Oncogene, 18:7900-7907 1999

Moynahan, M.E., Chiu, J.W., Koller, B.H., and Jasin, M. BRCA1 controls homology-directed DNA repair. Mol.Cell. 4, 511-518, 1999.

Byrum, R.S., Goulet, J.L., Snouwaert, J.N., Griffiths, R.J. and B.H. Koller. Determination of the Contribution of Peptidyl Leukotrienes and Leukotriene B4 in Acute Inflammatory Responses using 5-lypoxygenase- and LTA4 hydrolase-deficient Mice. J of Immunol. 163:6810-6819 1999.

Salvatore, C.A., Tilley, S.L., Latour, A.M., Fletcher, S., Koller, B.H. and M.A. Jacobson. Disruption of the A3 Adenosine Receptor Gene in Mice and its Effect on Stimulated Inflammatory Cells. JBC, 275:4429-4434, 2000.

Tilley, S.L. Wagoner, V.A., Salvatore, C.A., Jacobson, M.A., and B.H. Koller. Adenosine and inosine mediated increases in cutaneous vasopermeability occur through A3 receptor activation of mast cells. J Clin. Invest. 105:361-367 2000.

Goulet, J.L., Byrum, R.S., Key, M.L., Nguyen, M-T., Wagoner, V.A., and B.H. Koller. Genetic factors determine the contribution of leukotreines to acute inflammatory responses. J of Immunol. 164:4899-4907,2000.

Pace, A.J., Lee, E., Athirakul, K., Coffman, T.M., O’Brien, D., A., and B.H. Koller. Failure of spermatogenesis in mouse lines deficient in the Na+-K+-2Cl- cotransporter. J. Clin. Invest. 105:441-450,2000.

Bhattacharyya A. Ear US. Koller BH. Weichselbaum RR. Bishop DK. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51and survival following treatment with the DNA cross-linking agent cisplatin. JBC Chemistry. 275(31):23899-903, 2000.

Bennett LM. McAllister KA. Malphurs J. Ward T. Collins NK. Seely JC. Gowen LC. Koller BH. Davis BJ. Wiseman RW. Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol. Cancer Research. 60(13):3461-9, 2000.

Loftin, C.D. Trivedi, D.B., Tiano, H.F., Clark, J.A., Lee, C.A., Epstein, J.A., Morham, S.G., Breyer, M.D., Nguyen M-T, Hawkins, B.M., Goulet, J.L., Smithies, O., Koller, B.H., and R. Langenbach. Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2. PNAS 98: 1059-1064, 2001

Staudinger, J.L., Goodwin, B., Jones, S.A.., Hawkins-Brown, D., MacKenzie, K.I., Latour, A., Liu, Y., Klaassen, C.D., Brown, K.K., Reinhard, J., Willson, T.M., Koller, B.H. and S.A.. Kliewer. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. PNAS: 98(6):3369-3374, 2001.

Aprelikova, O, Pace, A. J. , Fang,B, Koller, B.H and E.T. Liu. BRCA1 is a co-regulator of 14-3-3 sigma gene expression, submitted, JBC in press
Backlund, M.G, Trasti, S.L, Backlund, D.C., Cressman,V.L, Godfrey, V., B.H. Koller. Impact of Ionizing Radiation and Genetic Background on Mammary Tumorigenesis in p53-Deficient Mice. Cancer Research in press

Fabre, J-E, Nguyen, M-T., Athirakul, K., Coggins, K., McNeish, J.D., Austin, S., FitzGerald, G.A., Parise, L.K., Coffman, T.M., and B.H. Koller. The prostaglandin EP3 receptor regulates Platelet Aggregation and Thrombosis. JCI 107(5)603-610 2001

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