Key words: systems biology, signal transduction, cell fate decisions
We study the behavior of individual cells and try to understand how groups of cells work together to carry out emergent functions. We are especially interested in “irreversible” cell fates such as apoptosis, senescence, and differentiation. How does a given cell convert molecular signals into a permanent decision? How do groups of cells balance these decisions? We use a variety of experimental and computational approaches to investigate these questions including molecular profiling, time-lapse microscopy, computational modeling, and machine learning. Our ultimate goal is to not only understand how cells make decisions under physiological conditions, but to discover how to manipulate these choices to treat disease.
We have openings for doctoral students from the Biological and Biomedical Sciences graduate program. Interested students are welcome to contact Jeremy for more information about our research projects.
We are looking for an outstanding Research Specialist and Laboratory Manager to work in our interdisciplinary research program. Interested candidates should have proven record of training in mammalian molecular biology. A Ph.D. and computational skills are highly preferred. Interested candidates should e-mail a cover letter, CV and a list of three references to Jeremy.